Study of Jatropha Gossypiifolia L. fruits extracts on leukemia screening transgenic mice

 Study of Jatropha Gossypiifolia L. fruits extracts on leukemia screening transgenic mice

Common name: Bellyache Bush, Cotton-leaf physic nut • Hindi: रतनजोती Ratanjoti • Manipuri: ꯏ ꯍꯤꯗꯥꯛ Ee hidak • Tamil: சிறிய ஆமணக்கு Siria Amanakku • Malayalam: Chuvanna Kadalavanakku • Kannada: ಚಿಕ್ಕಕಾಡಹರಳು Chikka kada haralu • Bengali: Lal bherenda

Jatropha gossypiifolia L. (Euphorbiaceae), widely known as “bellyache bush,” is a medicinal plant largely used throughout Africa and America. Several human and veterinary uses in traditional medicine are described for different parts and preparations based on this plant. However, critical reviews discussing emphatically its medicinal value are missing. This review aims to provide an up-to-date overview of the traditional uses, as well as the phytochemistry, pharmacology, and toxicity data of J. gossypiifolia species, in view of discussing its medicinal value and potential application in complementary and alternative medicine. Pharmacological studies have demonstrated significant action of different extracts and/or isolated compounds as antimicrobial, anti-inflammatory, antidiarrheal, antihypertensive, and anticancer agents, among others, supporting some of its popular uses.

Several human and veterinary uses in traditional medicine are described for different parts (leaves, stems, roots, seeds, and latex) and preparations (infusion, decoction, and maceration, among others) based on this plant, by different routes (oral or topical). The most frequent reports concern its antihypertensive, anti-inflammatory, antiophidian, analgesic, antipyretic, antimicrobial, healing, antianemic, antidiabetic, and antihemorrhagic activities, among many other examples . Other uses are also related to this plant, such as biodiesel production, pesticide, insecticide, vermifuge, ornamentation, and even its use in religious rituals

Various chemical constituents have been detected in extracts from different parts of J. gossypiifolia, the literature having reported, in general, the presence of fatty acids, sugars, alkaloids, amino acids, coumarins, steroids, flavonoids, lignans, proteins, saponins, tannins, and terpenoids.

What is a Complete Blood Count?

A complete blood count, or CBC, is a blood test that measures many different parts and features of your blood, including:

Red blood cells, which carry oxygen from your lungs to the rest of your body.

White blood cells, which fight infections and other diseases. There are five major types of white blood cells. A CBC test measures the total number of white cells in your blood. A different test called a CBC with differential measures the number of each type of these white blood cells.

Platelets, which stop bleeding by helping your blood to clot.

Hemoglobin, a protein in red blood cells that carries oxygen from your lungs to the rest of your body.

Hematocrit, a measurement of how much of your blood is made up of red blood cells.

Mean corpuscular volume (MCV), a measure of the average size of your red blood cells.

Other names for a complete blood count: CBC, full blood count, blood cell count

What is it used for?

A complete blood count is a common blood test that is often part of a routine checkup. Complete blood counts can help detect a variety of disorders including infections, anemia, diseases of the immune system, and blood cancers.

Blood component Normal levels red blood cell in men: 4.32-5.72 million cells/mcL

In women: 3.90-5.03 million cells/mcL

hemoglobinIn men: 135-175 grams/L

In women: 120-155 grams/L

hematocritIn men: 38.8-50.0 percent

In women: 34.9-44.5 percent

white blood cell count3,500 to 10,500 cells/mcL

platelet count150,000 to 450,000

(Medically reviewed by Debra Sullivan, Ph.D., MSN, R.N., CNE, COI — By Danielle Moores — Updated on September 17, 2018)

References

G. L. Webster, “Classification of the euphorbiaceae,” Annals of the Missouri Botanical Garden, vol. 81, pp. 3–143, 1994.

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M. V. Alves, “Checklist das espécies de Euphorbiaceae Juss. ocorrentes no semi-árido pernambucano, Brasil,” Acta Botância Brasileira, vol. 12, no. 3, pp. 485–495, 1998.

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C. W. Sabandar, N. Ahmat, F. M. Jaafar, and I. Sahidin, “Medicinal property, phytochemistry and pharmacology of several Jatropha species (Euphorbiaceae): a review,” Phytochemistry, vol. 85, pp. 7–29, 2013.

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C. K. A. Leal and M. D. F. Agra, “Estudo farmacobotânico comparativo das folhas de Jatropha molissima (Pohl) Baill,” Acta Farmaceutica Bonaerense, vol. 24, no. 1, pp. 5–13, 2005.

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L. C. Di Stasi and C. A. Hiruma-Lima, Plantas medicinais na Amazônia e na Mata Atlântica, UNESP, São Paulo, Brazil, 2nd edition, 2002.

M. D. F. Agra, K. N. Silva, I. J. L. D. Basílio, P. F. De Freitas, and J. M. Barbosa-Filho, “Survey of medicinal plants used in the region Northeast of Brazil,” Brazilian Journal of Pharmacognosy, vol. 18, no. 3, pp. 472–508, 2008.

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S. R. Mariz, A. C. R. Borges, M. F. F. Melo-Diniz, and I. A. Medeiros, “Possibilidades terapêuticas e riscos toxicológicos de Jatropha gossypiifolia L.: uma revisão narrativa,” Revista Brasileira De Plantas Medicinais, vol. 12, no. 3, pp. 346–357, 2010.

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I. Cordeiro and R. Secco, “Jatropha gossypiifolia L. Lista de espécies da flora do Brasil,” Jardim Botânico do Rio de Janeiro, Detalha Taxon Publico.

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U. P. de Albuquerque, P. M. de Medeiros, A. L. S. de Almeida et al., “Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: a quantitative approach,” Journal of Ethnopharmacology, vol. 114, no. 3, pp. 325–354, 2007.

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U. P. Albuquerque, L. H. C. Andrade, and J. Caballero, “Structure and floristics of homegardens in Northeastern Brazil,” Journal of Arid Environments, vol. 62, no. 3, pp. 491–506, 2005.

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