Evolution of Euphorbia Tithymaloides EXTRACTS ON ANTIVIRAL SCREENING MODELS

 

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Evolution of Euphorbia Tithymaloides EXTRACTS ON ANTIVIRAL SCREENING MODELS

Euphorbia tithymaloides (Devil's-backbone, Japanese Poinsettia, Redbird Flower, Slipper Flower)

Devil's backbone earned its common names because the interesting pattern the stems make as they grow. Devil's backbone is a dramatic upright houseplant that looks beautiful in a tall, upright planter to accent its shape.

Pedilanthus tithymaloides (L.) Poit. (Euphorbiaceae) is a low tropical American shrub with a reported wide range of healing properties such as emetic, anti-inflammatory, antibiotic, antiseptic, antihemorrhagic, antiviral, antitumoral, and abortive.

The root is known to be a powerful emetic. A proteolytic enzyme known as pedilanthain can be extracted from the plant's latex, and has been shown in experiments to be effective against intestinal worms and to reduce inflammation when http://ingested.In 1995, a galactose-specific lectin was purified from the plant's latex, and indications are that it might be useful in combatting diabetes mellitus.

In folk medicine, tea has been brewed from the leaves which has been used to treat asthma, persistent coughing, laryngitis, mouth ulcers, and venereal disease.Tea brewed from the root has been used as an abortifacient.The latex has been used topically to treat calluses, ear ache, insect stings, ringworm, skin cancer, toothache, umbilical hernias, and warts.None of these uses has been scientifically verified as effective. In the West Indies, a few drops of the latex is added to milk and used as an emetic.

The roots, stems, and leaves of the plant are known to be toxic.

The sap in the roots, stems and leaves of the devil's-backbone contain a number of carcinogenic compounds, such as euphorbol. Those who handle the plant may accidentally touch it, resulting in inflammation and irritation in the skin, and sometimes blistering.

EXTRACTS ACTIVITY OF Euphorbia Tithymaloides on antiviral screening methods

The in vivo activity of Herbs Extracts was demonstrated in animal models of HSV ocular, cutaneous,

genital, CNS and neonatal infections. Initiation of Herbs extracts administration within 24 hours of viral

challenge can reduce the establishment of viral latency following primary infection, but eradica

tion of established latent virus has not been achieved. Activity as a prophylactic agent has been demonstrated in rabbits with HSV keratitis. Combination with other antiviral agents, such as

vidarabine, ribavirin or ribonucleotide reductase inhibitors, has resulted in synergistic effects

against HSV infections selectively inhibits DNA replication of herpes viruses, with low host cell

toxicity. The antiviral is preferentially activated in infected cells; initial phosphorylation occurs

via viral thymidine kinase, and triphosphate (the active derivative obtained from the monophosphate via host cell enzymes) inhibits viral DNA polymerase more readily than the cellular enzyme, thus preventing viral replication. Although EpsteinBarr virus (EBV) appears to have only minimal thymidine kinase activity

Reference:

Steinmann, Victor W. "The Submersion of Pedilanthus into Euphorbia (Euphorbiaceae)." Acta Botanica Mexicana. 2003.

Strong, Asa B. The American Flora: Or History of Plants and Wild Flowers. New York: Strong and Bidwell, 1850.

Torkelson, Anthony R. The Cross Name Index to Medicinal Plants: Common Names, M-Z. New York: CRC Press, 1996.

Van Damme, Els J.M. Handbook of Plant Lectins: Properties and Biomedical Applications. Chichester, U.K.: Wiley, 1998.

Vardhana, Rashtra. Direct Uses of Medicinal Plants and Their Identification. New Delhi: Sarup & Sons, 2008.

Wijnands, D.O. The Botany of the Commelins. New York: CRC Press, 1983.

Drugs 47 (I): 153205, 1994

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