Effect of Carica papaya Linn. leaf extract on Epinephrine and ergotamine-induced tail gangrene model

 Effect of Carica papaya Linn. leaf extract on Epinephrine and ergotamine-induced tail gangrene model

Carica papaya Linn. (Caricaceae)

Carica papaya is a herbaceous succulent plant popularly known as pawpaw, and belongs to the Caricaceae family. It is native to the tropics of the Americas but now is widely cultivated in other tropical regions of the world for its edible melon-like fruit, which is available throughout the year . Different parts of the plant are employed in the treatment of different human and veterinary diseases in various parts of the world. For example, in Asian folk medicine, the latex is employed as an abortificient, antiseptic for wound dressing, and as a cure for dyspepsia. while in Africa, the root infusion is reputed for treating venereal diseases, piles, and yaws . In Cuba, the latex is used in the treatment of psoriasis, ringworm, and cancerous growth . Its fruit and seed extracts have been reported of possessing pronounced bactericidal activity against Staphylococcus aureus, Bacillus cereus, Escherischia coli, Pseudomonas aeruginosa, and Shigella flexneri . The pulverized seeds are also documented to possess antiparasitic activities against Entamoeba histolytica and Dirofilaria immitis infections . The sedative and muscle relaxant reversible antifertility and purgative properties of the plant extract have also been widely reported. Preclinical subchronic toxicity of 250, 500, and 1000 mg/kg of the aqueous leaf extract of Carica papaya have been reported to include hypoglycemia, hypolipidemia, improved hematological parameters while those of its ethanolic leaf extract include hyperuricemia, glomerulosclerosis, and tubular clarification, hepatotoxicity, hypoglycemia, and hypolipidemia .

Epinephrine and ergotamine-induced tail gangrene model:

Experiments were performed by a modification of the method of Lund (8). Male Wistar rats weighing 277-353g were used. Epinephrine (0.05 mg) was injected subcutaneously at both the ventral and dorsal side at a 6-cm distance from the tip of the rat tail. Simultaneously, ergotamine (2 mg/kg) was injected subcutaneously into the back. The length of gangrene in the tail was measured for 7 days. OP-41483 • a -CD and PGE1•CD (0.1, 0.3 and lug/kg/min) were infused as described above from 30 min beforeepinephrine and ergotamine injections for 7 days (24 hr/day). Cutaneous blood flow of the tail (3-cm length from the tip) was measured under pentobarbital anesthesia (30 mg/kg, i.p.) by a laser Doppler flow meter (Advance, ALF 2000) before and 5 days after the insults.

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