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Showing posts from July, 2022

EFFECT OF HIGH DOSED SWERTIA CHIRATA LINN. ON LIVER AND KIDNEY TOXICITY STUDY IN ALBINO RATS MODEL

  Swertia chirata Family Gentianaceae Ayurvedic nameKirata tikta Unani nameChirata Hindi nameChirayata Trade nameChirayataParts usedWhole plant Therapeutic uses Swertia chirata is a bitter tonic, carminative, laxative, anti-pyretic, febrifuge, anti-periodic, anti-inflammatory, stomachic, and anti-helmintic. It is used in treating piles, skin diseases, ulcers, and diabetes. Medicinal Uses S. chirayita a traditional Ayurvedic herb is used by different indigenous population groups in multiple ways for several medicinal purposes. The whole plant is widely used by local people for the treatment of hepatitis, inflammation, and digestive diseases (Bhatt et al., 2006). The wide range of medicinal uses include the treatment of chronic fever, malaria, anemia, bronchial asthma, hepatotoxic disorders, liver disorders, hepatitis, gastritis, constipation, dyspepsia, skin diseases, worms, epilepsy, ulcers, scanty urine, hypertension, melancholia, and certain types of mental disord...

AntiInflammatory and AntiArthritic Activity of Swertia chirata extracts in Rat Model

  Swertia chirata Family Gentianaceae Ayurvedic nameKirata tikta Unani nameChirata Hindi nameChirayata Trade nameChirayataParts usedWhole plant Therapeutic uses Swertia chirata is a bitter tonic, carminative, laxative, anti-pyretic, febrifuge, anti-periodic, anti-inflammatory, stomachic, and anti-helmintic. It is used in treating piles, skin diseases, ulcers, and diabetes. Medicinal Uses S. chirayita a traditional Ayurvedic herb is used by different indigenous population groups in multiple ways for several medicinal purposes. The whole plant is widely used by local people for the treatment of hepatitis, inflammation, and digestive diseases (Bhatt et al., 2006). The wide range of medicinal uses include the treatment of chronic fever, malaria, anemia, bronchial asthma, hepatotoxic disorders, liver disorders, hepatitis, gastritis, constipation, dyspepsia, skin diseases, worms, epilepsy, ulcers, scanty urine, hypertension, melancholia, and certain types of mental disorders, secretion o...

Protective Effect of Adansonia digitata L. 70% stem bark extracts on cisplatin and gamma irradiation-induced nephrotoxicity in male albino rats.

  The majestic baobab tree is an icon of the African continent and lies at the heart of many traditional African remedies and folklore. The baobab is a prehistoric species which predates both mankind and the splitting of the continents over 200 million years ago. Native to the African savannah where the climate is extremely dry and arid, it is a symbol of life and positivity in a landscape where little else can thrive.  Over time, the Baobab has adapted to its environment. It is a succulent, which means that during the rainy season it absorbs and stores water in its vast trunk, enabling it to produce a  nutrients dense fruit in the dry season when all around is dry and arid. This is how it became known as "The Tree of Life". Baobab trees grow in 32 African countries. They can live for up to 5,000 years, reach up to 30 metres high and up to an enormous 50 metres in circumference. Baobab trees can provide shelter, food and water for animals and humans, which is why many sav...

ANTI-AGING AND ANTIOXIDANT PROPERTIES OF LAPORTEA AESTUANS L. IN PHARMACOLOGICAL MODELS

  LAPORTEA AESTUANS Order: ROSALES Family: URTICACEAE Genus:  LAPORTEA Species: L. aestuans Synonyms Fleurya aestuans (L.) Gaudich. (1830), Laportea bathiei Leandri (1965). Vernacular names Stinging nettle, West Indian nettle, West Indian woodnettle (En). Origin and geographic distribution Laportea aestuans is widely distributed in tropical Africa, from Senegal eastward to Eritrea and southward to Angola, Zimbabwe and Mozambique, and in Madagascar. It also occurs in Yemen, tropical Asia and tropical America. Uses The stem yields a fibre used for thread, string and rope. The slightly mucilaginous leaves are often eaten as a vegetable and in soup. The plant is a preferred food of the edible giant snail Achatina achatina. Laportea aestuans is widely used in African traditional medicine. The pulped whole plant is eaten or the plant sap is drunk as an anthelmintic and for the treatment of hernia. Pulp of the whole plant is applied on the body in case of oedema and ulcers. The pulve...

ANTICANCER ACTIVITY OF SEMEN PROTEIN NANO SUSPENSION IN MICE MODEL

  ANTICANCER ACTIVITY Semen is a complex substance created by the male reproductive organs. The fluid is made mostly of water, plasma, and mucus (a lubricating substance). It also contains 5 to 25 calories and is made up of small amounts of essential nutrients including: Citrate Protiens Zinc Calcium Magnesium Potassium AntiCancerActivity Animals  A total of 60, 6–7-week-old, Swiss albino mice (weight range, 25–30 g) of both genders (Samtako Bio Korea, Osan, Korea), were divided into six groups, each consisting of 12 animals, and were used to assess biological activity. Animals were maintained in an air-conditioned room at a temperature of 22±1°C and a humidity of 55±1% with a 12 h light/dark cycle. They were fed a standard commercial rodent pellet diet (Samtako Bio Korea), and had ad libitum access to water. The animals were allowed to acclimate to the environment for seven days prior to the experimental session. All animal experiments ...

Neuroprotective Effects of Morus Alba Linn. leaves & fruit extracts Against Dopaminergic Neurodegeneration in Rotenone-Induced Rat Model of Parkinson’s Disease

  Introduction Parkinson’s disease (PD) is pathologically described by the continued loss of dopaminergic neuronal cells in the substantia nigra pars compacta (SNc), which results in motor impairments such as loss of motion, postural and gait instability, resting tremors, and muscle rigidity. Accumulating evidence suggests that mitochondrial dysfunction, lipid peroxidation, brain aging, and genetic susceptibility, which often involve oxidative stress and neuroinflammatory changes, play a major part in the pathogenesis of PD. Oxidative stress and inflammation are the two central pathways in microglial cells activation that lead to progressive neuronal degeneration and represent an important therapeutic target in PD. The activation and release of proinflammatory cytokines, such as IL-1β, IL-6, and TNFα, along with free radical generation including reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS), has detrimental effects on the existence of dopaminergic neurons...

CARCINOGENIC AND GENOTOXICITY STUDY OF MANGIFERA INDICA L. STEM BARK OIL IN WISTER ALBINO RATS ALONG ITS ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDY

  Mangifera indica  (family Anacardiaceae), commonly known as mango, is a pharmacologically, ethnomedically, and phytochemically diverse plant. Various parts of  M. indica  tree have been used in traditional medicine for the treatment of different ailments, and a number of bioactive phytochemical constituents of  M. indica  have been reported, namely, polyphenols, terpenes, sterols, carotenoids, vitamins, and amino acids, and so forth. Several studies have proven the pharmacological potential of different parts of mango trees such as leaves, bark, fruit peel and flesh, roots, and flowers as anticancer, anti-inflammatory, antidiabetic, antioxidant, antibacterial, antifungal, anthelmintic, gastroprotective, hepatoprotective, immunomodulatory, antiplasmodial, and antihyperlipemic. In the present review, a comprehensive study on ethnopharmacological applications, pharmacological activities, and bioactive compounds of  M. indica  has been described. T...

Evaluation of Antiviral, Antimicrobial, Antiifungal and Anthelmintic activity of Pyrus Communis leaves extract

  pyrus communis: Taxonomy Kingdom : Plantae Division : Magnoliophyta Class : Magnoliopside Order: Rosales Family: Rosaceae Subfamily: Amygdaloideae Tribe : Maleae Sub-tribe: Malinae Genus : Pyrus L. Species : Communis Linn. pyrus communis L. (pear) is an important medicinal plant that has been commonly used since prehistoric times. The pear is known as ‘Amritphale’ due to its immense effect in health care system of human. Different compounds have been detected in various parts of Pyrus communis L. like arbutin, kaempferol, quercetin, fredielin, isoquercitrin, sterols, ursolic acid, astragalin, sorbitol, phloridzin and tannins that are responsible for various activities of pear such as anti-oxidant, anti-microbial, anti- cancer, cholesterol-lowering, skin-whitening, anti-diabetic, wound healing effect, action on urinary system, immune booster and weight loss effect. Pyrus communis(pear) has many nutritional benefits as well as many medicinal uses. Pear is a swee...

Study on Anticancer Activity of Ficus Benghalensis on Wistar Albino Rats Treated with Diethyl Nitrosamine

  Ficus Benghalensis Also known as banyan fig or Indian banyan, the banyan tree is an unusually shaped tree that belongs to the family of mulberry. The botanical name of banyan tree is Ficus benghalensis. This tree does belong to the genus Ficus that comprises other species, like F. macrocarpa, F. pertusa, F. citrifolia, F. elastic, etc. Banyan tree acquires a height of 100 feet or 30 meters and spreads laterally open-endedly. The branches of this tree give rise to aerial roots that again take roots for becoming new trunks when they touch the soil. At times, a banyan tree assumes the look of a dense thicket due to the tangling of trunks and roots.  Benefits of a Banyan Tree Some remarkable benefits of a banyan tree for our health are as follows: A banyan tree treats diarrhoea – People suffering from diarrhoea can take small budding leaves from the banyan tree to soak them in water. It forms a sturdy astringent agent which is excellent to heal gas, diarrhoea, irritat...

Evaluation of nootropic activity of syzygium samatragense leaves in diazepam and scopolamine-induced amnesic mice and rats

  Syzygium samaragense KINGDOM Plantae SUB KINGDOM Tracheobionta (Vascular plants), SUPER DIVISION Spermatophyta (Seed plants) DIVISION Magnoliophyta (Flowering plants) CLASS Magnoliopsida (Dicotyledons) ORDER Myrtales FAMILY Myrtaceae GENUS Syzygium SPECIES Syzygium samaragense Wax apple studied for its numerous pharmacological properties such as antioxidant and antidiabetic properties, anti-inflammation and antinociceptive activity, wound healing activity, antiulcerogenic effect, antibacterial, anticancer and also it's potential as an uterotonic agent. Two flavonol glycoside have been isolated and characterised from leaves of sygygium samarangense . One is the rare mearnsitrin  (1)  while the second, 2′- C -methyl-5′- O -galloylmyricetin-3- O - a -l-rhamnopyranoside  (2) , is new. The  Syzygium samarangense  (Blume) Merr & Perry was first introduced in Taiwan and is now grown in Indonesia, Malaysia, Thailand and a few humid regio...

Hazards of GMOs foods on Human Beings, Environment and Natural Ayurveda Herbal Medicine in India

  Gentically modified organisms (GMOs) can be defined as organisms (i.e. plants, animals or microorganisms) in which the genetic material (DNA) has been altered in a way that does not occur naturally by mating and/or natural recombination. IT DECREASES THE POTENCY OF HERBAL MEDICINE AND MAY CAUSE TOXIC EFFECTS Unexpected effects and health risks posed by genetic engineering? 1. Toxicity 2. Allergic Reactions 3. Antibiotic Resistance 4. Immuno-suppression 5. Cancer 6. Loss of Nutrition India is out of the top five countries producing the most GM foods in terms of crop area after the United States (US), Brazil, Argentina & Canada. According to a 2018 study released by the Centre for Science & Environment (CSE), 21 out of 65 food samples tested from Delhi, Gujarat and Punjab were found GM positive. Out of those 21 GM foods, 16 were imported food items from Canada, Thailand, Netherland, United Arab Emirates (UAE) and the US. Based on the findings, here are some GM...

IMMUNOMODULATORY EFFECTS OF MORCHELLA ESCULENTA DRIED POWDER IN WISTAR ALBINO RATS

  Yellow morel Morchella esculenta Morchella esculenta, is a species of fungus with Family Morchellaceae of the Ascomycota. Scientific name: Morchella esculenta Kingdom: Fungi Order: Pezizales Family:  Morchellaceae Division: Ascomycota Morchella esculenta is well known both for its nutritional as well as health benefits. Fruiting body of Gucchi mushroom is nutritious. It is a source of many bioactive components such as polysaccharides, carbohydrates, dietary fibers, proteins, vitamins such as Vitamin A, Vitamin C and Vitamin D, trace elements which include calcium, magnesium, manganese, selenium, copper, zinc, iron, potassium and phosphorous. Morels carry high amount of Vitamin D, approximately 206 IU in 100 g of the sample. These mushrooms that are low in fat and contain low calories (Elmastas et al., 2016) reported that the fruiting body of Gucchi mushrooms exhibits antioxidant activity. The presence of β-carotene and linoleic aci...