Protective effects of Crocus Sativus Extracts on cadmium-induced infertility in male mice

 


Protective effects of Crocus Sativus Extracts on cadmium-induced infertility in male mice


Crocus sativus L. belonging to the family Iridaceae (syn - kesar) comprises the dried red stigma and is widely cultivated in Iran and other countries such as India and Greece. Saffron contains more than 150 volatile and aroma-yielding compounds mainly terpenes, terpene alcohol, and their esters. The bitter taste and an iodoform or hay-like fragrance are caused by chemicals picrocrocin and safranal. C. sativus possesses a number of medicinally important activities such as antihypertensive, anticonvulsant, antitussive, antigenototoxic and cytotoxic effects, anxiolytic aphrodisiac, antioxidant, antidepressant, antinociceptive , anti-inflammatory, and relaxant activity. It also improves memory and learning skills, and increases blood flow in retina and choroid.



Cadmium chloride

Cadmium chloride (CdCl2 2.5 H2O) was obtained from Sigma, St. Louis, MO, and dissolved in water. The mice inoculation was performed daily for four repeated days consecutively with different doses of CdCl2 (1, 3, 5 and 7 mg/kg body weight). As the dose of 3 mg/kg induced significant changes of seminiferous tubules in mice, this dose was approved in the experiments.

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